C. Mao

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Characterization of human XPD helicase activity with Single Molecule Magnetic Tweezers

This study measures the DNA unwinding and translocation activities of human XPD helicase using magnetic tweezers, revealing it is a partially active enzyme with slow unwinding rates and sequence-dependent behavior.

Structural Genomics of the Human Dopamine Receptor System

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

Mechanical Deformation Behaviors and Structural Properties of Ligated DNA Crystals

This study investigates the mechanical deformation and structural properties of ligated DNA crystals using simulations and experiments, revealing complex behaviors not predictable from individual components.

Lipidomic profiling reveals concerted temporal patterns of functionally related lipids in Aedes aegypti females following blood feeding

This study identifies temporal lipidomic changes in Aedes aegypti mosquitoes post-blood meal, highlighting functional lipid patterns linked to reproduction.

Anaerobic degradation of acid red 73 by obligately aerobic Aspergillus tabacinus LZ-M though a self-redox mechanism

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

Gait-symmetry-based human-in-the-loop optimization for unilateral transtibial amputees with robotic prostheses

This paper proposes a gait-symmetry-based human-in-the-loop optimization method for unilateral transtibial amputees, improving gait symmetry and reducing metabolic cost.

Structural basis of bile acid receptor activation and Gs coupling

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

VST Family Proteins are Regulators of Root System Architecture in Rice and Arabidopsis

This study identifies OsVST1 in rice and its homologs in Arabidopsis as regulators of root system architecture, showing conserved function and potential for agricultural optimization.

Analysis of the Mutant Selection Window and Killing of Mycoplasma hyopneumoniae for Doxycycline, Tylosin, Danofloxacin, Tiamulin, and Valnemulin

This study evaluates the mutant selection window and killing effects of five antibiotics against Mycoplasma hyopneumoniae, finding that danofloxacin, tylosin, and doxycycline are more likely to promote resistance than tiamulin and valnemulin.

Deep learning for cancer type classification

This study introduces DeepCues, a deep learning model that improves cancer type classification using DNA sequencing data, achieving 77.6% accuracy on TCGA data and showing significant improvement over conventional methods.

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

The paper introduces a multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues using various clearing protocols.

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases

This study investigates the catalytic mechanism of ACER3, identifying key residues and demonstrating its Zn2+-dependent activity similar to other Zn-based amidases.