M. Nakanishi

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.

This study shows plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts through the ESCRT pathway and Ca2+-p53 axis.

This study investigates how C9orf72-derived PR poly-dipeptides alter cytoskeletal structure and cell mechanics in mammalian cells.

This study shows that ATR inhibition increases 5-FU sensitivity in cancer cells, independent of DNA repair pathways.

The paper identifies 27-hydroxycholesterol's role in regulating URAT1/SLC22A12 gene expression through estrogen response elements, linking cholesterol metabolism to serum uric acid levels.

The paper compares epigenetic differences in human iPSCs generated by three different vectors and finds Sendai virus generates the fewest aberrant methylation sites.