Author

A. Kikuchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Harada· 1 shared A. Hayashi· 1 shared A. Niida· 1 shared A. Nishiyama· 1 shared A. Yamagata· 1 shared B.-C. Chen· 1 shared E. Betzig· 1 shared H. Eguchi· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Harada

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for activation of DNMT1

A. Kikuchi, H. Onoda, K. Yamaguchi, S. Kori, S. Matsuzawa, Y. Chiba, S. Tanimoto, S. Yoshimi, H. Sato, A. Yamagata, M. Shirouzu, N. Adachi, J. Sharif, H. Koseki, A. Nishiyama, , K. Arita

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

bioRxiv · Jun 16, 2022Biochemistry

Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion.

A. Kikuchi, A. Harada, S. Matsumoto, Y. Yasumizu, T. Akama, H. Eguchi

This study identifies ARL4C's role in pancreatic cancer invasion by localizing it to membrane protrusions and showing its interaction with IQGAP1 and MMP14, leading to extracellular matrix degradation and metastasis suppression via ASO.

bioRxiv · Feb 23, 2021Cancer Biology

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

Y. Kawasaki, T. Hamaji, K. Owada, A. Hayashi, Y. Wu, T. Nogi, M. Okada, S. Sakai, N. Tokushige, S. Sasagawa, H. Nakagawa, Y. Kouyama, A. Niida, K. Mimori, T. Kuroda, , Y. Mimori-Kiyosue

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

bioRxiv · Sep 18, 2020 · PreprintCell Biology