Real-time visualization reveals Mycobacterium tuberculosis ESAT-6 disrupts phagosome via fibril-mediated vesiculation
D. Koiri, M. Nandi, A. H. PM, A. J. Bhausaheb, G. Meher, A. Behura, A. Kumar, V. Choudhary, S. Choubey, M. Saleem
This study reveals how ESAT-6 disrupts the phagosomal membrane through fibril-mediated vesiculation, leading to host cell death and promoting Mtb infection.
bioRxiv · Apr 19, 2024 · PreprintBiophysics