L. Premkumar

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains

This study evaluates a stabilized DENV2 E homodimer vaccine, finding it elicits broader neutralizing antibody responses targeting multiple E protein domains compared to the wild-type monomer.

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition

This study examines B cell and antibody responses to SARS-CoV-2 antigens in individuals with and without post-COVID condition (PCC), finding sex-related differences in antibody responses to the spike protein.

Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

This study defines the epitope and neutralization mechanism of a human antibody targeting Zika virus by showing that cross-linking of viral envelope proteins is critical for neutralization.

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

The paper assesses immunological memory to Common Cold Coronaviruses over three years and finds sustained CD4+ T cell and antibody responses, suggesting stable memory rather than frequent reinfections.

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

SARS-CoV-2 mRNA Vaccine Induces Robust Specific and Cross-reactive IgG and Unequal Strain-specific Neutralizing Antibodies in Naïve and Previously Infected Recipients

This study examines antibody responses to SARS-CoV-2 mRNA vaccines in naive and previously infected individuals, finding robust IgG and varying neutralizing antibody levels against different variants.

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

This study evaluates the in vitro antiviral activity of three Ebola and Marburg virus inhibitors against SARS-CoV-2 and explores their potential mechanisms of action.

Engineered variants provide new insight into the structural properties important for activity of the highly dynamic, trimeric protein disulfide isomerase, PmScsC

The paper characterizes two variants of PmScsC, showing how oligomerization and domain spacing affect disulfide isomerase activity.