Author

Y. Durocher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Assay:proteomics· 4 Organism:human· 2 Assay:protein sequence· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Stuible· 5 shared A. Tran· 2 shared C. Gervais· 2 shared D. Duque· 2 shared S. Perret· 2 shared A. Cantin· 1 shared A. Gamarnik· 1 shared A. J. I. Quenum· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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5 shared papersImmunology

M. Stuible

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

C. M. Ives, L. Nguyen, C. A. Fogarty, A. M. Harbison, Y. Durocher, J. S. Klassen, e. fadda

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

bioRxiv · Dec 5, 2023Biophysics

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective againstOmicron

D. Bottero, E. Rudi, P. M. Aispuro, M. E. Zurita, M. E. Gaillard, M. M. G. L. Ledesma, J. Malito, M. Stuible, N. M. Ambrosis, Y. Durocher, A. Gamarnik, A. Wigdorovitz, D. Hozbor

This study evaluates the effectiveness of heterologous booster vaccines against Omicron BA.1 using a mouse model, showing that mRNA-based vaccines outperform vector-based ones, while heterologous boosters improve immune responses.

bioRxiv · Oct 5, 2023Immunology

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition

M.-A. Limoges, A. J. I. Quenum, M. M. H. Chowdhury, F. Rexhepi, M. Namvarpour, S. A. Akbari, C. Rioux-Perreault, M. Nandi, J.-F. Lucier, S. Lemaire-Paquette, L. Premkumar, Y. Durocher, A. Cantin, S. Levesque, A. Menendez, , S. Ramanathan

This study examines B cell and antibody responses to SARS-CoV-2 antigens in individuals with and without post-COVID condition (PCC), finding sex-related differences in antibody responses to the spike protein.

bioRxiv · Apr 13, 2023 · PreprintImmunology

BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine

D. J. Perera, P. Domenech, G. G. Babuadze, M. Naghibosadat, F. Alvarez, C. Koger-Pease, L. Labrie, M. Stuible, Y. Durocher, C. A. Piccirillo, A. Lametti, P. O. Fiset, S. M. Elahi, G. P. Kobinger, R. Gilbert, , M. Ndao

BCG enhances anti-SARS-CoV-2 immunity and protection afforded by a novel adenovirus-vectored vaccine.

bioRxiv · Mar 21, 2023Immunology

Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters

F. C. Stark, B. Akache, L. Deschatelets, A. Tran, M. Stuible, Y. Durocher, M. J. McCluskie, G. Agbayani, R. Dudani, B. A. Harrison, T. M. Renner, S. R. Makinen, J. Bavananthasivam, D. Duque, C. D. Zarley, , J. Zimmermann

This study evaluates an intranasal vaccine formulation containing a proteosome-adjuvanted SARS-CoV-2 Spike protein, showing immunogenicity and efficacy in mice and hamsters against multiple variants.

bioRxiv · Mar 2, 2022 · PreprintImmunology

Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns

M. A. Rossotti, H. van Faassen, A. Tran, J. Sheff, J. A. Sandhu, D. Duque, M. Hewitt, S. Wen, R. Bavananthasivam, S. Beitari, K. Matte, G. Laroche, P. M. Giguere, C. Gervais, M. Stuible, , J. Tanha

This paper presents a diverse set of nanobodies targeting SARS-CoV-2 spike glycoprotein with broad neutralization activity against multiple variants and high in vivo efficacy.

bioRxiv · Dec 20, 2021 · PreprintBioengineering

Rapid, high-yield production of full-length SARS-CoV-2 spike ectodomain by transient gene expression in CHO cells

M. Stuible, C. Gervais, S. Lord-Dufour, S. Perret, D. L'Abbe, J. Schrag, G. St-Laurent, Y. Durocher

The paper develops a method to rapidly produce high-yield, full-length SARS-CoV-2 spike protein using CHO cells and reports yields of 100-150 mg/L.

bioRxiv · Sep 8, 2020Bioengineering

A simple protein-based surrogate neutralization assay for SARS-CoV-2

K. T. Abe, Z. Li, R. Samson, P. Samavarchi-Tehrani, E. J. Valcourt, H. Wood, P. Budylowski, A. P. Dupuis, R. C. Girardin, B. Rathod, K. Colwill, A. J. McGeer, S. Mubareka, J. L. Gommerman, Y. Durocher, , A.-C. Gingras

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

bioRxiv · Jul 10, 2020Immunology