The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice.
P. K. Jena, D. Wakita, A. C. Gomez, T. T. Carvalho, A. E. Atici, M. Narayanan, Y. Lee, M. C. Fishbein, P. D. Cani, W. M. de Vos, D. M. Underhill, S. Devkota, S. Chen, K. Shimada, T. R. Crother, , M. N. Rivas
This study shows that gut microbiota depletion reduces cardiovascular inflammation in a mouse model of Kawasaki disease, and specific bacteria or their metabolites can alleviate vasculitis by improving gut barrier function.
bioRxiv · May 28, 2024Immunology