Author

K. Shimada

Friedrich Miescher Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Ikeda· 1 shared A. Ishii· 1 shared Alexandra M. BendeliD· 1 shared Bastian Eichenbergers· 1 shared Charlotte SonesoniD· 1 shared Dirk SchübeleriD· 1 shared Dominique Klein· 1 shared E. Kobayashi· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBioengineering

A. Ikeda

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Author profile →

5 papers

Recent·Most cited

The genetic architecture of the human bZIP family

Alexandra M. Bendel, Bastian Eichenbergers, Georg Kempf, Dominique Klein, K. Shimada, M. Franco, S.H.W. Kraatz, Sevi Durdu, Vivian Herrmann, Grégory Roth, Charlotte Soneson, Sébastien A. Smallwood, Nicolas H Thomae, Dirk Schübeler, Michael Beda Stadler, , Guillaume Diss

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

bioRxiv · Aug 21, 2025 · PreprintBiophysics

Generation of human-pig chimeric renal organoids using iPSC technology

K. Fujimori, S. Yamanaka, K. Shimada, K. Matsui, S. Kawagoe, T. Kuroda, A. Ikeda, M. Inoue, E. Kobayashi, T. Yokoo

This study generates human-pig chimeric renal organoids using modified human-mouse chimeric methods, demonstrating successful interspecies kidney development.

bioRxiv · Mar 19, 2024Bioengineering

SARS-CoV-2 causes brain inflammation via impaired neuro-immune interactions

N. Oka, K. Shimada, A. Ishii, N. Kobayashi, K. Kondo

This study develops a mouse model of SARS-CoV-2-induced brain inflammation and identifies impaired cholinergic anti-inflammatory pathway as a mechanism, suggesting donepezil as a potential treatment.

bioRxiv · Jul 13, 2022 · PreprintMicrobiology

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice

X. Zhang, J. Sun, Y. Lu, J. Zhang, K. Shimada, T. Noda, S. Zhao, T. Koyano, M. Matsuyama, S. Zhou, J. Wu, M. Ikawa, M. Liu

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

Journal of Cell Science · Oct 21, 2021Peer-reviewedCell Biology

A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs

K. Shimada, J. L. Muchlich, T. J. Mitchison

The paper introduces a user-friendly browser for the Cancer Dependency Map that predicts drug efficacy and selectivity based on gene dependencies in cancer cell lines.

bioRxiv · Dec 13, 2019 · PreprintCancer Biology