Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs
F. Bork, C. L. Greve, C. Youn, S. Chen, Y. Wang, M. Nasri, J. Focken, J. Scheurer, P. Engels, M. Dubbelaar, K. Hipp, B. Schittek, S. Bugl, M. W. Loeffler, J. Skokowa, , A. N. Weber
This study identifies naRNA as a pre-assembled composite DAMP in neutrophils that drives NET formation and inflammation via TLR8/TLR13, redefining NETs as intentional inflammatory agents.
bioRxiv · Jul 26, 2022 · PreprintImmunology