Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus
A. Kengmo Tchoupa, A. M. A. Elsherbini, X. Fu, O. Ghaneme, L. Seibert, M. A. Boecker, M. Lebtig, J. Camus, S. Papadopoulos Lambidis, B. Schittek, D. Kretschmer, M. Laemmerhofer, A. Peschel
This study identifies Lip2 as a Staphylococcus aureus lipase that detoxifies antimicrobial fatty acids via esterification with cholesterol, revealing its role in skin colonization resistance.
bioRxiv · May 15, 2023Microbiology