Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2
S. Swaminathan, K. Lineburg, G. Ambalathingal, P. Crooks, E. Grant, S. Mohan, J. Raju, A. Panikkar, L. Le Texier, Z. Tong, K. Chew, M. Neller, H. Gowda, K. Short, S. Gras, , R. Khanna
The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.
bioRxiv · Oct 13, 2021 · PreprintImmunology