Author

S. Gras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Smith· 3 shared C. Szeto· 3 shared A. T. Nguyen· 2 shared C. A. Lobos· 2 shared D. Jayasinghe· 2 shared E. J. Grant· 2 shared K. L. Good-Jacobson· 2 shared L. Cooper· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

C. Smith

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

L. Cooper, H. Xu, J. Polmear, C. Szeto, E. S. Pang, M. Gupta, J. J. Taylor, K. J. L. Jackson, A. Nguyen, N. La Gruta, L. G. Martelotto, I. A. Parish, M. O'Keeffe, C. D. Scharer, S. Gras, K. L. Good-Jacobson

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

bioRxiv · Mar 2, 2023Immunology

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

C. R. Pothast, R. C. Dijkland, M. Thaler, R. S. Hagedoorn, M. G. Kester, A. K. Wouters, P. S. Hiemstra, M. J. van Hemert, S. Gras, J. F. Falkenburg, M. H. Heemskerk

The paper shows that CMV-specific T cells can cross-react with SARS-CoV-2, contributing to pre-existing immunity despite low sequence homology.

bioRxiv · Jul 31, 2022Immunology

Stable and ancient endocytic structures navigate the complex pellicle of apicomplexan parasites

L. Koreny, B. N. Mercado-Saavedra, C. M. Klinger, K. Barylyuk, S. Butterworth, J. Hirst, Y. Rivera-Cuevas, N. R. Zaccai, V. J. C. Holzer, A. Klingl, J. B. Dacks, V. B. Carruthers, M. S. Robinson, S. Gras, R. F. Waller

This study identifies stable endocytic structures in Toxoplasma, showing their conservation across Apicomplexa and their role in plasma membrane homeostasis rather than nutrition.

bioRxiv · Jun 2, 2022 · PreprintCell Biology

COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals

A. T. Nguyen, C. Szeto, D. S. M. Chatzileontiadou, Z. W. M. Tong, M. J. Dewar-Oldis, L. Cooper, L. D. Murdolo, K. Y. Chew, K. E. Lineburg, A. Riboldi-Tunicliffe, R. Williamson, B. J. Gardiner, D. Jayasinghe, C. A. Lobos, Y. M. Ahn, , S. Gras

bioRxiv · Jan 12, 2022 · PreprintImmunology

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

S. Swaminathan, K. Lineburg, G. Ambalathingal, P. Crooks, E. Grant, S. Mohan, J. Raju, A. Panikkar, L. Le Texier, Z. Tong, K. Chew, M. Neller, H. Gowda, K. Short, S. Gras, , R. Khanna

The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.

bioRxiv · Oct 13, 2021 · PreprintImmunology

Molecular basis of a dominant SARS-CoV-2 Spike-derived epitope presented by HLA-A*02:01 recognised by a public TCR

C. Szeto, A. T. Nguyen, C. A. Lobos, D. S. Chatzileontiadou, D. Jayasinghe, E. J. Grant, A. Riboldi-Tunnicliffe, C. Smith, S. Gras

The paper reports the X-ray structure of a public TCR recognizing a SARS-CoV-2 Spike-derived epitope and shows its activation of polyfunctional CD8+ T cells in recovered patients.

bioRxiv · Aug 15, 2021Immunology