H. Gowda

CRISPR-Cas13d screens identify KILR a breast cancer risk-associated lncRNA that regulates DNA replication and repair.

The paper identifies KILR, a breast cancer risk-associated lncRNA, and shows it regulates DNA replication and repair by sequestering RPA1.

Regulation of Non-Canonical Proteins Encoded by Small Open Reading Frames via the Nonsense-Mediated Decay Pathway.

This study investigates how UPF1 knockdown affects non-canonical/mutant protein expression and reveals its role in suppressing neoantigen availability through the NMD pathway in cancer.

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

EpCAM Aptamer siRNA chimeras: Therapeutic efficacy in epithelial cancer cells.

This study demonstrates that EpCAM aptamer-siRNA chimeras effectively silence oncogenes in epithelial cancers, leading to tumor reduction and apoptosis.

Identification of lncRNAs associated with early stage breast cancer and their prognostic implications

This study identifies differentially expressed long non-coding RNAs in early-stage breast cancer and evaluates their prognostic significance using RNA sequencing and TCGA datasets.