M. Noda

Convolutional neural network model detected lasting behavioral changes in mouse with kanamycin-induced unilateral inner ear dysfunction

The paper uses a convolutional neural network to detect lasting behavioral changes in mice with unilateral inner ear dysfunction induced by kanamycin.

Deletion or inhibition of PTPRO mitigates diet-induced hepatic steatosis and inflammation in obesity

This study shows that deleting or inhibiting PTPRO reduces hepatic steatosis and inflammation in obese mice, improving metabolic health.

Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication

This study reports the crystal structure of SARS-CoV-2 main protease bound to Vitamin C, showing its potential as an inhibitor of viral replication.

Simple amplicon sequencing library preparation for plant root microbial community profiling

The paper develops a simplified high-throughput method for 16S rRNA gene amplicon sequencing of plant root microbiota, showing improved microbial diversity capture compared to standard methods.

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals

This paper shows that Ebselen inhibits SARS-CoV-2 main protease 3CLpro by destroying its crystal diffraction power, suggesting it as a potential antiviral agent.

Structural basis for ligand-induced inactivation of protein tyrosine receptor type Z (PTPRZ): Physiological relevance of head-to-toe RPTP dimerization

This study reveals that PTN-induced inactivation of PTPRZ occurs through head-to-toe dimerization of its tandem PTP domains, which is critical for OPC differentiation.