Cell BiologybioRxiv
Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
A. Härtlova, I. Fabrik, O. Bilkei-Gorzo…·M. Göransson
This study identifies cathepsin K as a key determinant of lung macrophage phagosome function, essential for collagen degradation and regulated by TGF-β and cigarette smoke.