J. Fuchs

Long live the host! Proteomic analysis reveals possible strategies for parasitic manipulation of its social host

This study identifies parasite-secreted proteins and host proteome changes in ants infected with Anomotaenia brevis, revealing strategies for host manipulation through antioxidant proteins and altered translational activity.

Plasticity in centromere organization: Holocentromeres can consist of merely a few megabase-sized satellite arrays

The paper analyzes the holocentromere organization in Chionographis japonica, revealing that its holocentromeres consist of few, large satellite arrays and differ from other holocentric species.

Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen

This study identifies cathepsin K as a key determinant of lung macrophage phagosome function, essential for collagen degradation and regulated by TGF-β and cigarette smoke.

Impaired immune response drives age-dependent severity of COVID-19

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

High temperature increases centromere-mediated genome elimination frequency in Arabidopsis deficient in cenH3 or its assembly factor KNL2

The paper shows that high temperature increases genome elimination in Arabidopsis mutants lacking cenH3 or its assembly factor KNL2, enhancing haploid induction efficiency.

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization

This study shows that intranasal adenoviral vector boosts after mRNA priming enhance mucosal immunity and protection against SARS-CoV-2 in mice.

Precursor types predict the stability of neuronal branches

The paper shows that neuronal branch stability depends on precursor types, with filopodia-derived branches being more stable than those from lamellipodia or growth cone splitting, and PLPPR3 enhances filopodia-based branching.

The structure of enteric human adenovirus 41 - a leading cause of diarrhoea in children

This study determines the structure of enteric HAdV-F41 using cryo-EM, revealing structural differences from non-enteric HAdVs that explain its tissue tropism and pathogenicity.

Analysis of the small chromosomal Prionium serratum (Cyperid) demonstrates the importance of a reliable method to differentiate between mono- and holocentricity

The study analyzes Prionium serratum chromosomes to determine centromere organization, finding monocentricity instead of holocentricity and suggesting holocentricity evolved independently in two lineages.

Island songbirds as windows into evolution in small populations

This study examines island songbird genomes to test predictions about evolutionary forces in small populations, finding lower genetic diversity and reduced adaptive potential.

Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth

This study analyzes the genome and time-of-day transcriptome of Wolffia australiana to link its extreme morphological minimization with reduced circadian regulation and continuous growth.

Absolute quantification of cohesin, CTCF and their regulators in human cells

The paper measures absolute copy numbers and dynamics of cohesin, CTCF, and related proteins in human cells, revealing that some genomic enrichment sites are unoccupied in single cells.