Hypermetabolism in mice carrying a near complete human chromosome 21
D. C. Sarver, C. Xu, S. Rodriguez, S. Aja, A. E. Jaffe, F. J. Gao, M. Delannoy, M. Periasamy, Y. Kazuki, M. Oshimura, R. H. Reeves, G. W. Wong
This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.
bioRxiv · Jan 30, 2023Physiology