PhysiologybioRxiv
Hypermetabolism in mice carrying a near complete human chromosome 21
D. C. Sarver, C. Xu, S. Rodriguez…·G. W. Wong
This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.
DOI 10.7554/elife.86023