Author

S. Aja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. C. Sarver· 2 shared G. W. Wong· 2 shared A. Cammarato· 1 shared A. E. Jaffe· 1 shared A. Wolfe· 1 shared A.-C. Wei· 1 shared C. C. Talbot· 1 shared C. M. Antonescu· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPhysiology

D. C. Sarver

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Author profile →

4 papers

Recent·Most cited

Loss of CTRP10 results in female obesity with preserved metabolic health

F. Chen, D. C. Sarver, M. Saqib, L. M. Velez, S. Aja, M. M. Seldin, G. W. Wong

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

bioRxiv · Nov 1, 2023Physiology

Hypermetabolism in mice carrying a near complete human chromosome 21

D. C. Sarver, C. Xu, S. Rodriguez, S. Aja, A. E. Jaffe, F. J. Gao, M. Delannoy, M. Periasamy, Y. Kazuki, M. Oshimura, R. H. Reeves, G. W. Wong

This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.

bioRxiv · Jan 30, 2023Physiology

CaMKII oxidation is a performance/disease trade-off in vertebrate evolution

Q. Wang, E. O. Hernandez-Ochoa, M. C. Viswanathan, I. D. Blum, J. M. Granger, K. R. Murphy, A.-C. Wei, S. Aja, N. Liu, C. M. Antonescu, L. D. Florea, C. C. Talbot, D. Mohr, K. R. Wagner, S. Regot, , M. E. Anderson

This study shows CaMKII oxidation by ROS evolved in vertebrates to enhance performance but increased disease risk.

bioRxiv · Sep 13, 2019Evolutionary Biology

Ablation of tanycytes of the arcuate nucleus and median eminence increases visceral adiposity and decreases insulin sensitivity in male mice.

S. Yoo, D. Cha, S. Kim, L. Jiang, M. Adebesin, A. Wolfe, R. Riddle, S. Aja, S. Blackshaw

This study shows that ablating tanycytes in male mice increases visceral fat and reduces insulin sensitivity, but not body weight or food intake.

bioRxiv · May 16, 2019Physiology