Y. Kuroda

Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker

This study identifies αvβ5 integrin as a marker for activated tumor-resident Tregs in PDAC, showing that targeting it enhances immune checkpoint therapy.

Disorganization of basement membrane zone architecture causes impaired melanocyte inhabitation in vitiligo

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

The biophysical nature and not only the size of protein aggregates determines the strength of the immune response against dengue ED3

This study shows that the biophysical properties of protein aggregates, not just their size, influence immune response strength using dengue virus protein D3ED3.

Biophysical analysis of Gaussia Luciferase bioluminescence mechanisms using a non-oxidizable coelenterazine.

The paper investigates the bioluminescence mechanism of Gaussia Luciferase using azacoelenterazine, revealing the role of salt and monovalent anions and structural changes in catalysis.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

Thermodynamic analysis of point mutations inhibiting high-temperature reversible oligomer of PDZ3

The paper shows that mutating hydrophobic residues at the PDZ3 oligomeric interface inhibits high-temperature reversible oligomerization, as evidenced by DSC analysis showing a single endothermic peak.

Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR

This paper determines the solution structure of Gaussia Luciferase using NMR and identifies a potential coelenterazine binding cavity involved in bioluminescence.

Systematic mutational analysis of epitope-grafted ED3's immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

The paper identifies a chimeric ED3 mutant that generates antisera serospecific to both DENV3 and DENV4, revealing that epitope grafting alone is insufficient for serospecificity transfer.

A systematic mutational analysis identifies a 5-residue proline tag that enhances the in vivo immunogenicity of a non-immunogenic model protein 240 folds

Generation of nanometer-size aggregates using Solubility Controlling Peptide tags and their ability to increase a proteins immunogenicity in vivo

This study shows that nanometer-scale protein aggregates can increase immunogenicity in vivo, using BPTI-19A as a model.

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription

The paper identifies a ZCCHC10-PITX1 complex that suppresses hTERT transcription, contributing to telomerase regulation in melanoma.