M. Paci

A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents

This paper develops an atrial-specific in-silico model of stem cell-derived cardiomyocytes integrating IKur and IKCa currents, validated against experimental data to improve drug testing and understanding of atrial fibrillation.

All-optical electrophysiology refines populations of in silico human iPS-CMs for drug evaluation

This paper combines all-optical electrophysiology with in silico models to refine human hiPS-CMs for drug evaluation, showing accurate prediction of drug effects and adverse events.