Author

S. Severi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:electrophysiology· 4 Organism:human· 4 Approach:statistical model· 4 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Bartolucci· 2 shared M. Paci· 2 shared A. Fabbri· 1 shared A. Klimas· 1 shared A. Loewe· 1 shared A. Varro· 1 shared B. Rodriguez· 1 shared C. Altomare· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

C. Bartolucci

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents

S. Botti, C. Bartolucci, C. Altomare, M. Paci, L. Barile, R. Krause, L. F. Pavarino, S. Severi

This paper develops an atrial-specific in-silico model of stem cell-derived cardiomyocytes integrating IKur and IKCa currents, validated against experimental data to improve drug testing and understanding of atrial fibrillation.

bioRxiv · Jan 12, 2024 · PreprintBioengineering

Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models

C. Campana, E. Ricci, C. Bartolucci, S. Severi, E. A. Sobie

This study uses mathematical modeling to show that intercellular coupling and cellular heterogeneity protect the sinoatrial node from ionic perturbations in both healthy and diseased conditions.

bioRxiv · Apr 14, 2022Physiology

All-optical electrophysiology refines populations of in silico human iPS-CMs for drug evaluation

M. Paci, E. Passini, A. Klimas, S. Severi, J. Hyttinen, B. Rodriguez, E. Entcheva

This paper combines all-optical electrophysiology with in silico models to refine human hiPS-CMs for drug evaluation, showing accurate prediction of drug effects and adverse events.

bioRxiv · Oct 9, 2019Pharmacology & Toxicology

Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium

A. Loewe, Y. Lutz, N. Nagy, A. Fabbri, C. Schweda, A. Varro, S. Severi

The paper investigates inter-species differences in sinus node pacemaking response to changes in extracellular calcium using computational models of mouse, rabbit, and human cells.

bioRxiv · Sep 18, 2019 · PreprintCell Biology