Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
C. Qi, P. Lavriha, E. Bayraktar, A. Vaithia, D. Schuster, M. Pannella, V. Sala, P. Picotti, M. Bortolozzi, V. M. Korkhov
The paper presents cryo-EM structures of wild-type and CMT1X mutant connexin 32 gap junction channels and hemichannels, revealing a gating helix defect in disease-associated mutants.
bioRxiv · Mar 8, 2023Biophysics