Author

A. Vaithia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

P. Lavriha· 3 shared V. M. Korkhov· 3 shared C. Qi· 2 shared D. Schuster· 2 shared P. Picotti· 2 shared X. Ding· 2 shared B. Khanppnavar· 1 shared E. Bayraktar· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

P. Lavriha

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Author profile →

3 papers

Recent·Most cited

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

P. Lavriha, Y. Han, X. Ding, C. Qi, A. Vaithia, V. M. Korkhov

The paper identifies two distinct binding sites for connexin channel inhibitors mefloquine and 2APB, showing they block channel function through different mechanisms.

bioRxiv · Dec 11, 2023 · PreprintBiochemistry

Structural basis of connexin-36 gap junction channel inhibition

X. Ding, S. Aureli, A. Vaithia, P. Lavriha, D. Schuster, B. Khanppnavar, X. Li, T. B. Blum, P. Picotti, F. L. Gervasio, V. M. Korkhov

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

bioRxiv · Dec 9, 2023Biophysics

Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels

C. Qi, P. Lavriha, E. Bayraktar, A. Vaithia, D. Schuster, M. Pannella, V. Sala, P. Picotti, M. Bortolozzi, V. M. Korkhov

The paper presents cryo-EM structures of wild-type and CMT1X mutant connexin 32 gap junction channels and hemichannels, revealing a gating helix defect in disease-associated mutants.

bioRxiv · Mar 8, 2023Biophysics