PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis
V. C. Sladky, K. Knapp, T. G. Szabo, L. Bongiovanni, H. van den Bos, D. C. J. Spierings, B. Westendorp, T. Stojakovic, H. Scharnagl, G. Timelthaler, K. Tsuchia, M. Pinter, F. Foijer, A. de Bruin, T. Reiberger, , A. Villunger
This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.
bioRxiv · May 13, 2020 · PreprintCancer Biology