Cancer BiologybioRxivPreprint
PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis
V. C. Sladky, K. Knapp, T. G. Szabo…·A. Villunger
This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.