Author

M. Raman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:C. elegans· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. Ganji· 3 shared S. Mukkavalli· 3 shared J. A. Klickstein· 2 shared P. Juo· 2 shared B. A. Ahlstedt· 1 shared B. Ortiz· 1 shared C. C. Weihl· 1 shared C. L. Dahlberg· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

R. Ganji

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Author profile →

5 papers

Recent·Most cited

UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation independently of the p97 ATPase

B. A. Ahlstedt, R. Ganji, S. Mukkavalli, J. Paolo, S. P. Gygi, M. Raman

This study identifies UBXN1 as a negative regulator of the UPR that represses translation and maintains ER proteostasis independently of p97.

bioRxiv · Dec 16, 2022 · PreprintCell Biology

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and composition

R. Ganji, J. Paulo, Y. Xi, I. Kline, J. Zhu, C. S. Clemen, C. C. Weihl, J. G. Purdy, S. Gygi, M. Raman

This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.

bioRxiv · Dec 8, 2021 · PreprintCell Biology

The p97-UBXN1 complex regulates aggresome formation

S. Mukkavalli, J. A. Klickstein, B. Ortiz, P. Juo, M. Raman

This study shows that the p97-UBXN1 complex is essential for aggresome formation and clearance, with UBXN1 specifically required for proper aggresome assembly and reduced polyQ aggregate formation in Huntington's disease models.

bioRxiv · Sep 3, 2020Cell Biology

AggreCount: An unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatial manner

M. Raman, J. A. Klickstein, S. Mukkavalli

AggreCount is an ImageJ macro that identifies and quantifies cellular aggregates in a spatial manner, providing metrics like total number, localization, and per-cell statistics.

bioRxiv · Jul 25, 2020Cell Biology

The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation

M. Hodul, R. Ganji, C. L. Dahlberg, M. Raman, P. Juo

This study shows that WDR-48 stabilizes USP-46 by preventing its ubiquitination and degradation, highlighting a conserved mechanism for regulating DUB availability.

bioRxiv · Jun 21, 2019Biochemistry