Author
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3 papers
Recent·Most cited
B. A. Ahlstedt, R. Ganji, S. Mukkavalli…·M. Raman
This study identifies UBXN1 as a negative regulator of the UPR that represses translation and maintains ER proteostasis independently of p97.
S. Mukkavalli, J. A. Klickstein, B. Ortiz…·M. Raman
This study shows that the p97-UBXN1 complex is essential for aggresome formation and clearance, with UBXN1 specifically required for proper aggresome assembly and reduced polyQ aggregate formation in Huntington's disease models.
M. Raman, J. A. Klickstein, S. Mukkavalli
AggreCount is an ImageJ macro that identifies and quantifies cellular aggregates in a spatial manner, providing metrics like total number, localization, and per-cell statistics.