Y. Xi

Bioengineering a plant NLR immune receptor with a robust binding interface towards a conserved fungal pathogen effector

The paper bioengineers a plant NLR receptor to recognize a conserved fungal effector, resulting in durable resistance against blast fungus isolates.

YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

Airway secretory cell-derived p63+ progenitors contribute to alveolar regeneration after sterile lung injury

MNRR1 activation by nitazoxanide abrogates lipopolysaccharide- induced preterm birth in mice

The paper shows that nitazoxanide prevents preterm birth in mice by activating MNRR1, which counteracts inflammation caused by intra-amniotic LPS.

LabGym: quantification of user-defined animal behaviors using learning-based holistic assessment

LabGym quantifies user-defined animal behaviors using a learning-based approach, providing holistic assessment without pre-defined features or species restrictions.

MicroRNA-like snoRNA-derived RNAs (sdRNAs) promote castration resistant prostate cancer

This study identifies two snoRNA-derived fragments, sdRNA-D19b and sdRNA-A24, that promote castration-resistant prostate cancer by downregulating tumor suppressors and conferring drug resistance.

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and composition

This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.

FANCD2 and RAD51 recombinase directly inhibit DNA2 nucleases at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability

This study shows FANCD2 inhibits DNA2 nuclease activity and stabilizes RAD51 filaments to protect stalled replication forks, promoting genome stability.

Human Cytomegalovirus uses a Host Stress Response to Balance the Elongation of Saturated/Monounsaturated and Polyunsaturated Very Long Chain Fatty Acids

This study shows that PERK, part of the ER stress pathway, differentially regulates fatty acid elongation enzymes to balance lipid synthesis in HCMV-infected cells, supporting viral replication.

Design of a new effector recognition specificity in a plant NLR immune receptor by molecular engineering of its integrated decoy domain

This study demonstrates that molecular engineering of the integrated decoy domain of an NLR can expand its effector recognition spectrum to a new effector.

A H3K9me2-Binding Protein AGDP3 Limits DNA Methylation and Transcriptional Gene Silencing in Arabidopsis

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

Hypoxia-inducible factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis

This study shows HIF1 suppresses HCMV replication by limiting kynurenine synthesis and AhR signaling.

Evaluation of exosome-encapsulated miR-23a/b in the diagnosis of human coronary heart diseases

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

VIL1, a Polycomb-associated protein, modulates high ambient temperature response via H3K27me3 and H2A.Z in Arabidopsis thaliana

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

Human Cytomegalovirus Remodeling of Lipid Metabolism Requires pUL37x1

This study shows that the HCMV protein pUL37x1 is required for lipid metabolism remodeling but not central carbon metabolism hijacking during infection.