Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.
C. A. Johnson, J. E. McGreig, C. D. Vera, D. P. Mulvihill, M. Ridout, L. A. LEINWAND, M. N. Wass, M. A. Geeves
The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.
bioRxiv · Jul 2, 2019 · PreprintBiochemistry