C. D. Vera

Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties

The paper analyzes myosin motor domain mutations in Hypertrophic Cardiomyopathy to compare early and late onset mutations, finding no clear functional differences but identifying distinct changes from DCM mutations.

Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.

The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.