M. N. Wass

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

This study evaluates the antiviral efficacy of interferon-beta combined with antiviral drugs against SARS-CoV-2 variants, finding synergistic effects with certain drugs against specific variants.

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

This study shows that SARS-CoV-2 Omicron variants are more sensitive to interferon treatment than Delta variants, suggesting interferons could be effective therapies for Omicron infections.

This study compares drug sensitivity and interferon antagonism between Omicron and Delta SARS-CoV-2 variants, finding similar drug responses but reduced interferon antagonism in Omicron.

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

This study analyzes SAMHD1's role in cancer using TCGA and TARGET databases, finding no consistent tumour suppressor effect and suggesting context-dependent pro-or anti-tumourigenic effects.

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

The paper analyzes variability in drug response data from standardized cell culture experiments and finds high intrinsic variability even among well-controlled experiments.

The paper identifies transferrin as a potential coagulation promoter in COVID-19, showing age-related increases, sex differences, and upregulation upon infection.

This study compares SARS-CoV-2 and SARS-CoV in cell tropism and drug sensitivity, finding differences in conservation, receptor usage, and therapeutic responses to aprotinin and remdesivir.

This study tests YM155 in 101 neuroblastoma cell lines, revealing ABCB1 and ABCC1 as mediators of resistance and highlighting cross-resistance differences between drug-adapted lines.

The paper investigates drug-induced heterogeneity in cancer cell lines and identifies biomarkers for acquired resistance to YM155.

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.

The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.

This study shows that doxorubicin-loaded human serum albumin nanoparticles enhance anti-cancer activity in drug-resistant neuroblastoma cells by bypassing ABCB1-mediated efflux.

This study compares the anti-cancer activity of doxorubicin-loaded nanoparticles made from different polymers and preparation methods, finding significant differences in efficacy based on size, drug load, and release kinetics.

This paper shows that omeprazole enhances acyclovir's effectiveness against herpes simplex virus 1 and 2 in cell cultures without harming cell viability.