ImmunologyCancer Immunology ResearchPeer-reviewed
Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors
M. Righi, I. Gannon, M. Robson…·M. Pule
This paper introduces a dimerization domain from IgG1 antibodies to create engineered cytokine receptors that mimic natural heterodimerization, enhancing CAR T cell therapy efficacy.
DOI 10.1158/2326-6066.cir-22-0640