C. Allen

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia

This study shows that Ralstonia pseudosolanacearum lectins and EPS I have dual roles in biofilm attachment and mechanics depending on environmental flow conditions.

Genotypic and Phenotypic Analyses Show Ralstonia solanacearum Cool Virulence is a Quantitative Trait Not Restricted to 'Race 3 biovar 2'

The paper analyzes genotypic and phenotypic data to show that cool virulence in Ralstonia solanacearum is a quantitative trait not exclusive to R3bv2 strains.

The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease

This paper shows that inhibiting SRPK1 in monocytes promotes angiogenesis by altering VEGF splicing from anti-angiogenic VEGF-A165b to pro-angiogenic VEGF-A165a in both human and mouse models of peripheral arterial disease.

A Comprehensive Model of Blood Flow Restriction in the Post-surgical Rat

This paper introduces a comprehensive protocol for implementing blood flow restriction exercise in awake rats following ACL-R to study its effects on muscle growth and atrophy.

Deep Learning Model Imputes Missing Stains in Multiplex Images

The paper introduces a deep learning model, MAXIM, to impute missing protein markers in multiplex images, improving efficiency in staining and imaging processes.

Effectiveness and residual activity of four common insecticides used in the Mississippi Delta to control tarnished plant bugs in cotton

This study evaluates the effectiveness and residual activity of four insecticides against tarnished plant bugs in cotton, finding organophosphates most effective with high mortality rates.

Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors

This paper introduces a dimerization domain from IgG1 antibodies to create engineered cytokine receptors that mimic natural heterodimerization, enhancing CAR T cell therapy efficacy.

Ralstonia solanacearum pandemic lineage strain UW551 overcomes inhibitory xylem chemistry to break tomato bacterial wilt resistance

This study identifies that the Ralstonia solanacearum strain UW551 overcomes tomato resistance by detoxifying phenolic compounds in xylem sap.

Plant pathogenic Ralstonia phylotypes evolved divergent respiratory strategies and behaviors to thrive in xylem

This study shows that Ralstonia phylotypes use different respiratory strategies for virulence in plant xylem, with some relying on complete denitrification and others on partial denitrification.

Cell-density regulated adhesins contribute to early disease development and adhesion in Ralstonia solanacearum

This study identifies three adhesins in Ralstonia solanacearum that contribute to early disease development and adhesion during plant colonization.

Triggered Release from Thermosensitive Liposomes Improves Tumor Targeting of Vinorelbine

This study evaluates thermosensitive liposomes with vinorelbine and mild hyperthermia for improved tumor targeting in a murine rhabdomyosarcoma model, showing enhanced therapeutic index.

Fine-scale variability in coral bleaching and mortality during a marine heatwave

This study tracks coral bleaching and mortality during a marine heatwave, finding that spatial and taxonomic differences in bleaching are driven by environmental factors, habitat complexity, and species composition.

Folate receptor targeted nanoparticles containing niraparib and doxorubicin for treatment of high grade serous ovarian cancer

This paper demonstrates the synergistic potential of niraparib and doxorubicin in ovarian cancer treatment and develops folate receptor-targeted nanoparticles for their delivery.

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

This study combines thermosensitive liposomes, localized hyperthermia, and immune checkpoint inhibition to enhance systemic anti-tumor effects in a murine model of rhabdomyosarcoma.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Validating methods to eradicate Select Agent and phylotype I Ralstonia solanacearum strains reveals that growth in planta increases bacterial stress tolerance

This paper validates methods to eradicate Ralstonia solanacearum strains, showing that bacteria in planta are more stress-tolerant than cultured cells.

NorA, HmpX, and NorB cooperate to reduce NO toxicity during denitrification and plant pathogenesis in Ralstonia solanacearum

This paper shows that NorA, HmpX, and NorB work together to reduce NO toxicity in Ralstonia solanacearum during denitrification and plant infection, with double mutants showing severe growth defects.

Trehalose increases tomato drought tolerance, induces defenses, and increases resistance to bacterial wilt disease

This study shows that exogenous trehalose improves tomato drought tolerance and bacterial wilt resistance by enhancing ABA and SA signaling, and triggering systemic disease resistance.

Network-Based Discovery of Opioid Use Vulnerability in Rats Using the Bayesian Stochastic Block Model

The paper identifies three distinct behavioral sub-populations in rats with varying opioid vulnerability using a Bayesian stochastic block model.

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants

The paper characterizes a novel ACE2-based therapeutic that effectively neutralizes SARS-CoV-2 variants and demonstrates antibody-like properties and manufacturability.

Nitric Oxide Regulates the Ralstonia solanacearum Type 3 Secretion System

This study shows that nitric oxide (NO) from denitrification activates the Type III Secretion System (T3SS) in Ralstonia solanacearum during infection.

Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue and myofibers are a major source ex vivo but not in vivo.

The paper compares EV secretion between skeletal muscle and white adipose tissue, finding SkM secretes more EVs ex vivo, but myofiber-derived EVs rarely enter circulation in vivo.

Lamprey Lecticans Link New Vertebrate Genes to the Origin and Elaboration of Vertebrate Tissues

This study investigates the evolution of the lectican gene family in sea lampreys to understand its role in vertebrate tissue development.

Repeated gain and loss of a single gene modulates the evolution of vascular pathogen lifestyles

The paper shows that the gene cbsA acts as a switch for vascular vs. non-vascular pathogenesis in bacteria, with its presence and absence linked to lifestyle evolution.

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

This study shows PD-L1 CAR-engineered NK cells kill cancer cells and inhibit tumor growth by targeting PD-L1, reducing myeloid cells in both preclinical models and patient blood.

Low contribution of rare species to resilience and adaptive capacity in novel spatial regimes arising from biome shifts caused by global change

The paper assesses the contribution of rare species to resilience and adaptive capacity in novel spatial regimes caused by biome shifts, finding low overall contribution and no conservation concern.

Roq1 confers resistance to Xanthomonas, Pseudomonas syringae and Ralstonia solanacearum in tomato

Roq1, a tomato immune receptor, provides strong resistance to three bacterial pathogens: Xanthomonas, Pseudomonas syringae, and Ralstonia solanacearum.

Ralstonia solanacearum depends on catabolism of myo-inositol, sucrose, and trehalose for virulence in an infection stage-dependent manner

This study shows Ralstonia solanacearum uses different carbon sources at different infection stages, with LCD sources needed early and HCD sources required for late-stage virulence.

Predicting and Analyzing the Response to Selection on Correlated Characters

The paper evaluates how well the breeder's equation predicts evolutionary responses to bivariate selection in butterflies, finding improved predictions when environmental effects are accounted for.