M. Rousseau

Investigating the effects of protons versus x-rays on radiation-induced lymphopenia after brain irradiation

This study compares the effects of proton and x-ray irradiation on lymphopenia and tissue response in mice, finding protons reduce lymphocyte depletion and tissue inflammation.

Tissue-resident memory T cells mediate mucosal immunity to recurrent urinary tract infection

The paper shows that tissue-resident memory T cells (TRM) are necessary and sufficient for immune memory against recurrent urinary tract infections.

Identification of sex differences in tumor-specific T cell infiltration in bladder tumor-bearing mice treated with BCG immunotherapy

This study investigates sex differences in tumor-specific T cell infiltration in bladder cancer models treated with BCG immunotherapy, finding sex-based differences in CD8+ T cell infiltration and exhaustion markers.

Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder

The paper identifies two distinct bladder macrophage subsets, shows their differential responses to infection, and demonstrates their impact on immune outcomes.

The immune system fails to mount a protective response to Gram-positive or Gram-negative bacterial prostatitis

This study shows that immune responses to bacterial prostatitis do not prevent reinfection, as bacterial burden remains high despite adaptive immune activation.

Sex differences in IL-17 determine chronicity in male versus female urinary tract infection

The paper investigates sex differences in urinary tract infection (UTI) severity, finding that male mice develop chronic infections due to impaired innate immunity, while females exhibit robust IL-17-driven responses that promote bacterial clearance.