D. Duffy

High-dimensional spectral cytometry panels for whole blood immune phenotyping

The paper develops high-dimensional spectral flow cytometry panels for immune phenotyping in healthy donors and applies them to study immune variation in autoimmune diseases.

Targeting the chemokine receptor CXCR4 with histamine analogue to reduce inflammation in juvenile arthritis: a proof of concept for COVID-19 therapeutic approach

This study shows that targeting CXCR4 with clobenpropit reduces inflammation in juvenile arthritis and COVID-19 by lowering cytokine levels and immune cell activity.

Constitutive IFNα protein production in bats

This study shows that healthy bats have constitutively active IFN protein levels in their blood, independent of age, sex, or health, suggesting a unique antiviral mechanism.

Differential levels of IFNα subtypes in autoimmunity and viral infection

The paper develops an ultrasensitive ELISA for IFN2 and applies it to study IFN subtype responses in viral infection and autoimmunity, revealing distinct protein ratios and potential auto-antibody effects.

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses

The paper examines how tuberculosis alters immune-metabolic pathways, leading to changes in IL-1 responses in TB patients compared to latent infection and post-treatment.

SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance

This study shows SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance, potentially facilitating viral spread to the deeper lung.

Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes

This study identifies heterozygous RELA mutations in early-onset SLE patients, showing they drive type-I interferon gene expression through NF-κB pathway hijacking.

Stability and dynamics of the human gut microbiome and its association with systemic immune traits

The paper analyzes gut microbiome data from 946 donors to show age-related changes in bacterial profiles and links them to immune traits, supporting personalized microbial therapeutics.

Immune profiling in M. tuberculosis infection enables stratification of patients with active disease

This study compares TruCulture and QFT methods for detecting active TB, finding TruCulture better distinguishes active disease from latent infection using IFN-gamma and cytokine responses.

Sex differences in IL-17 determine chronicity in male versus female urinary tract infection

The paper investigates sex differences in urinary tract infection (UTI) severity, finding that male mice develop chronic infections due to impaired innate immunity, while females exhibit robust IL-17-driven responses that promote bacterial clearance.