Polyglutamylation of microtubules drives neuronal remodeling
A. Gavoci, A. Zhiti, M. Ruskov, M. M. Magiera, M. Wang, K. A. Ziegler, T. J. Hausrat, S. Engelhardt, M. Kneussel, M. Balastik, C. Janke, T. Misgeld, M. S. Brill
The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.
bioRxiv · Mar 11, 2024Cell Biology