S. Engelhardt

Polyglutamylation of microtubules drives neuronal remodeling

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

This study shows resident macrophages improve cardiac remodelling while recruited macrophages influence infarct size after myocardial ischemia/reperfusion injury.

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function

The paper identifies lncRNAs in cardiac resident macrophages and shows Schlafenlnc regulates macrophage migration.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

Barley guanine nucleotide exchange factor HvGEF14 is an activator of the susceptibility factor HvRACB and supports host cell entry by Blumeria graminis f.sp. hordei

This study identifies HvGEF14 as a guanine nucleotide exchange factor that activates HvRACB, a susceptibility factor for fungal entry in barley.

Barley RIC157 is involved in RACB-mediated susceptibility to powdery mildew

This study identifies RIC157 as a RACB-interacting protein that enhances barley susceptibility to powdery mildew by facilitating fungal penetration.

ROP INTERACTIVE PARTNER b interacts with RACB and supports fungal penetration into barley epidermal cells

The paper identifies RIPb as a downstream interactor of RACB in barley that enhances susceptibility to powdery mildew fungus by localizing to microtubules and the plasma membrane during haustoria formation.

Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination

The paper identifies phosphorylation and ubiquitination of the plant ROP RACB, showing conserved ubiquitination sites across species and their role in protein stability.