Cell BiologybioRxiv
Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.
C. Bussi, J. M. Peralta Ramos, D. S. Arroyo…·P. Iribarren
This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.
DOI 10.1242/jcs.226241