Author

C. Bussi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

M. G. Gutierrez· 3 shared B. Aylan· 2 shared D. S. Arroyo· 2 shared E. M. Bernard· 2 shared E. Pellegrino· 2 shared J. M. Peralta Ramos· 2 shared N. Athanasiadi· 2 shared P. Iribarren· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

M. G. Gutierrez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Physiologic media renders human iPSC-derived macrophages permissive for M. tuberculosis by rewiring organelle function and metabolism

C. Bussi, R. Lai, N. Athanasiadi, M. G. Gutierrez

This study shows that using a human plasma-like medium enhances M. tuberculosis replication in iPSC-derived macrophages by altering lipid metabolism and organelle function.

bioRxiv · Mar 15, 2024 · PreprintCell Biology

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

bioRxiv · Aug 9, 2022Cell Biology

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

P. Santucci, B. Aylan, L. Botella, E. M. Bernard, C. Bussi, E. Pellegrino, N. Athanasiadi, M. G. Gutierrez

This paper uses live-cell imaging to show that pyrazinamide disrupts Mycobacterium tuberculosis intracellular pH homeostasis, unlike other antibiotics, and that this effect depends on host endolysosomal acidification and PncA activity.

bioRxiv · Dec 20, 2021Microbiology

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain.

E. A. Gaviglio, J. M. Peralta Ramos, D. S. Arroyo, C. Bussi, P. Iribarren, M. C. Rodriguez-Galan

This study shows that systemic co-expression of IL-12 and IL-18 leads to IFN-γ-dependent microglia activation and recruitment of inflammatory monocytes into the brain, contributing to neuroinflammation.

bioRxiv · Jul 30, 2020Immunology

Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.

C. Bussi, J. M. Peralta Ramos, D. S. Arroyo, J. I. Gallea, P. Ronchi, A. Kolovou, J. M. Wang, O. Florey, M. S. Celej, Y. Schwab, N. T. Ktistakis, P. Iribarren

This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.

bioRxiv · Jul 27, 2017Cell Biology