Cancer BiologybioRxiv
Genomic evolution of non-small cell lung cancer patient-derived xenograft models
R. E. Hynds, A. Huebner, D. R. Pearce…·C. Swanton
This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.
DOI 10.1038/s41467-024-47547-3