C. Hall

Population sequencing for diversity and transmission analyses

This paper introduces and validates population sequencing methods to analyze phylogenetic diversity in bacterial populations without haplotype reconstruction, demonstrating applications in tracking transmission and understanding pathogen dynamics.

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells

The paper designs 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells using a combination of computational and experimental methods.

Back to the Future: Unleashing your cytometers spectral potential

This paper demonstrates that traditional flow cytometers can be used as spectral cytometers by unmixing data acquired from them.

Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced bactericidal activity

The paper shows infection-experienced HSPCs generate neutrophils with enhanced bactericidal activity, contributing to trained immunity and suggesting therapeutic strategies for infectious diseases.

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

Insights into early stages of the establishment of host:algal endosymbioses: Genetic responses to live versus heat-killed algae and bacterial prey in a sponge host

This study examines gene expression changes in a sponge host exposed to live and heat-killed algae and bacteria, identifying unique genetic responses to algal symbionts.

Prenatal cadmium exposure alters proliferation in mouse CD4+ T cells via LncRNA Snhg7

This study shows prenatal cadmium exposure increases lncSnhg7 and GALNT7 in mouse CD4+ T cells, enhancing proliferation through miR-34a regulation.

Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring

This study investigates whether prenatal cadmium exposure increases autoimmunity risk in offspring, finding no significant differences in autoimmune disease onset or severity.

Freshwater sponge hosts and their green algae symbionts: a tractable model to understand intracellular symbiosis

This study examines the intracellular symbiosis between freshwater sponge Ephydatia muelleri and its green algal symbionts, identifying host responses and potential evolutionary pathways for stable mutualistic endosymbioses.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

Universal rules of life: metabolic rates, biological times and the equal fitness paradigm

The paper reviews and extends the equal fitness paradigm to link metabolism, energy allocation, and universal rules of life across ecological and evolutionary scales.

Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population

This study identifies tumor cell-organized fibronectin as essential for maintaining dormant breast cancer populations through in vitro experiments.

Prepubertal gonadectomy reveals sex differences in approach-avoidance behavior in adult mice

This study shows that prepubertal gonadectomy leads to sex-specific changes in approach-avoidance behaviors in adult mice, suggesting different hormonal mechanisms underlie similar phenotypes.

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

Hotspot mutations and ColE1 plasmids contribute to the fitness of Salmonella Heidelberg in poultry litter

This study shows that plasmids and hotspot mutations enhance the survival of S. Heidelberg in poultry litter by increasing fitness and antibiotic resistance.

Brucella Peptide Cross-Reactive MHC I Presentation Activates SIINFEKL-Specific TCR Expressing T Cells

The paper shows that Brucella peptides can activate SIINFEKL-specific TCR-expressing T cells through cross-reactivity, suggesting immune evasion and potential autoimmunity.