Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action
A. Trifan, D. Gorgun, Z. Li, A. Brace, M. Zvyagin, H. Ma, A. R. Clyde, D. A. Clark, M. Salim, D. Hardy, T. Burnley, L. Huang, J. McCalpin, M. Emani, H. Yoo, , A. Ramanathan
This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.
bioRxiv · Oct 9, 2021 · PreprintBiophysics