Author

M. Samso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. R. Nayak· 2 shared A. H. Will· 1 shared A. Nayak· 1 shared G. D. Lamb· 1 shared J. J. Lobo· 1 shared J. Zhao· 1 shared K. Dryden· 1 shared M. S. Donnenberg· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. R. Nayak

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3 papers

Recent·Most cited

Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor

M. Samso, A. R. Nayak, W. Rangubpit, A. H. Will, Y. Hu, P. Castro-Hartmann, J. J. Lobo, K. Dryden, G. D. Lamb, P. Sompornpisut

The paper determines cryo-EM structures of RyR1 with Mg2+ and identifies multiple Mg2+ binding sites, revealing its inhibitory mechanism and interaction with gating helices.

bioRxiv · Feb 16, 2024Biophysics

Cryo-EM structure of the Type IV pilus extension ATPase from enteropathogenic Escherichia coli

A. R. Nayak, P. K. Singh, J. Zhao, M. Samso, M. S. Donnenberg

The paper reports the cryo-EM structures of the BfpD ATPase from EPEC in different nucleotide states, revealing divergent quaternary configurations and suggesting a new mechanism for T4P extension.

bioRxiv · Aug 10, 2022Microbiology

Ca2+-inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM

A. Nayak, M. Samso

This study uses cryo-EM to reveal two conformations of RyR1 under Ca2+ conditions, showing how Ca2+ binding inactivates the channel through structural changes.

bioRxiv · Nov 14, 2021Physiology