A human RNA ligase that operates via auto- and RNA-AMPylation
Y. Yuan, F. M. Stumpf, L. A. Schlor, O. P. Schmidt, L. B. Huber, M. Frese, E. Hoellmueller, M. Scheffner, F. Stengel, K. Diederichs, A. Marx
This study identifies C12orf29 as a human 5-3 RNA ligase that uses auto- and RNA-AMPylation to catalyze RNA ligation and maintain RNA integrity under stress.
bioRxiv · Jul 18, 2022 · PreprintBiochemistry