G. Dittmar

Microtubule association of TRIM3 revealed by differential extraction proteomics

The paper identifies TRIM3 as a novel microtubule-binding protein using differential extraction proteomics and shows its role in acetylated tubulin accumulation.

A genome-wide overexpression screen reveals Mycobacterium smegmatis growth inhibitors encoded by mycobacteriophage Hammy

The paper identifies 24 gene products from Mycobacteriophage Hammy that inhibit Mycobacterium smegmatis growth through a genome-wide overexpression screen.

Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

This study identifies a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells using proximity proteomics and mass spectrometry.

Non-targeted metabolomics identifies erythronate accumulation in cancer cells

The paper identifies erythronate accumulation in cancer cells using non-targeted metabolomics and suggests it may serve as a cancer biomarker.

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts

This study identifies two tryptophan-rich proteins essential for Plasmodium berghei blood-stage growth and sequestration of infected red blood cells.

LUBAC assembles a signaling platform at mitochondria for signal amplification and shuttling of NF-ĸB to the nucleus

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.

Highly multiplexed targeted plasma proteomics quantifies several hundred blood proteins in serum from colorectal carcinoma patients

This study uses targeted plasma proteomics to quantify 565 blood proteins in CRC patients and identifies 16 differentially regulated proteins correlated with mRNA expression in tumor samples.

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy

This study identifies PKA-mediated phosphorylation of ATG16L1 as a mechanism to limit autophagy and regulate angiogenesis in endothelial cells.

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ

The paper uses PRISMA to map C/EBPβ's PTM-dependent interactome, revealing interaction footprints and functional links to chromatin and RNA processing.