The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma
J. H. Raymond, M. Schonau, V. Petit, Z. Aktary, F. Luciani, M. Wehbe, I. Davidson, C.-L. Tomasetto, F. Mahuteau-Betzer, B. Vergier, L. Larue, V. Delmas
This study identifies an E-cadherin-ER-GRPR axis that drives sex-specific melanoma metastasis and shows GRPR inhibition reduces metastasis in vivo.
bioRxiv · Dec 2, 2022 · PreprintCancer Biology