Author

L. Larue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Z. Aktary· 3 shared C. Kenny· 2 shared E. Steingrimsson· 2 shared F. Rambow· 2 shared I. Davidson· 2 shared R. Cornell· 2 shared V. Delmas· 2 shared V. Petit· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Z. Aktary

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

J. P. Catani, A. Smet, T. Ysenbaert, M. Vuylsteke, G. Bottu, J. Mathys, A. Botzki, G. Cortes-Garcia, T. Strudnell, R. Gomila, J. Hamberger, J. Catalan, I. Ustyugova, T. Farrell, S. Stegalkina, , T. U. Vogel

This study analyzes the antigenic diversity of N2 neuraminidases from 2009-2017 H3N2 influenza viruses and develops a machine learning method to predict the impact of mutations on NA inhibition.

eLife · May 28, 2024Peer-reviewedImmunology

The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma

J. H. Raymond, M. Schonau, V. Petit, Z. Aktary, F. Luciani, M. Wehbe, I. Davidson, C.-L. Tomasetto, F. Mahuteau-Betzer, B. Vergier, L. Larue, V. Delmas

This study identifies an E-cadherin-ER-GRPR axis that drives sex-specific melanoma metastasis and shows GRPR inhibition reduces metastasis in vivo.

bioRxiv · Dec 2, 2022 · PreprintCancer Biology

Dynlt3, a novel fundamental regulator of melanosome movement, distribution, maturation and transfer

Z. Aktary, A. Conde, F. Rambow, M. Di Marco, F. Amblard, I. Hurbain, G. Raposo, C. Delevoye, S. Coscoy, L. LARUE

This study identifies Dynlt3 as a critical regulator of melanosome transport, maturation, and transfer in melanocytes, revealing its role in skin pigmentation through interactions with the Wnt/β-catenin pathway.

bioRxiv · Jan 13, 2021 · PreprintCell Biology

BRN2 is a non-canonical melanoma tumor-suppressor

M. Hamm, P. Sohier, V. Petit, J. Raymond, V. Delmas, M. Le Coz, F. Gesbert, C. Kenny, Z. Aktary, M. Pouteaux, F. Rambow, A. Sarasin, A. Bellacosa, L. Sanchez-del-Campo, L. Mosteo, , L. Larue

This study identifies BRN2 as a non-canonical tumor suppressor in melanoma, showing its role in initiation and progression through PTEN regulation and PI3K signaling.

bioRxiv · Jan 13, 2021Cancer Biology

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

A. Swoboda, R. Soukup, K. Kinslechner, B. Wingelhofer, D. Schoerghofer, C. Sternberg, H. Pham, M. Vallianou, J. Horvath, D. Stoiber, L. Kenner, L. Larue, V. Poli, F. Beermann, T. Yokota, , R. Moriggl

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.

Oncogene · Dec 15, 2020Peer-reviewedCancer Biology

MITF reprograms the extracellular matrix and focal adhesion in melanoma

R. Dilshat, V. Fock, C. Kenny, I. Gerritsen, R. M. J. Lasseur, O. Eichhoff, J. Travnickova, P. Cerny, K. Moller, S. Sigurbjornsdottir, K. Kirty, B. O. Einarsdottir, P. F. Cheng, M. Levesque, R. Cornell, , E. Steingrimsson

This study shows MITF represses ECM and focal adhesion genes in melanoma, affecting cell morphology and matrix interactions, with reversible effects observed upon MITF knockdown.

bioRxiv · Jul 14, 2020Cancer Biology