M. Screen

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

The paper integrates proteome and transcriptome data from mouse B cells to identify poised mRNAs and translational regulators involved in activation and antibody secretion.

The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition.

The paper identifies YTHDF2 as an m6A binding protein that promotes B cell to plasma cell transition in vitro and in chimeric mice.