M. Turner

Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.

Epi-microRNA mediated metabolic reprogramming ensures affinity maturation

This study identifies miR-155's role in metabolic reprogramming of GC-B cells to support affinity maturation under hypoxic conditions.

Zfp36l1 establishes the high affinity CD8 T cell response by directly linking TCR affinity to cytokine sensing

The paper shows ZFP36L1 links TCR affinity to cytokine sensing, promoting clonal expansion of high affinity CD8 T cells through IL2 competition.

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

The paper integrates proteome and transcriptome data from mouse B cells to identify poised mRNAs and translational regulators involved in activation and antibody secretion.

Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets

This study investigates how C3 toxins enter host cells by tracking fluorescently labeled C3larvinA and shows that lysosomal swelling and lysis are critical for toxin delivery to the cytoplasm.

Does fatigue influence joint-specific work and ground force production during the first steps of maximal accelerative running?

This study examines how fatigue affects joint-specific work and ground force production during the first steps of maximal accelerative running, finding that athletes maintain acceleration rate through compensatory changes in joint function.

Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells

This study shows PTBP1 is essential for optimal expansion and effector function of antigen-specific CD8 T cells, regulating splicing, mRNA abundance, and NFAT protein nuclear accumulation.

Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)

This paper investigates the CD46 receptor utilization by Ad26 in vitro and in vivo, showing its role in infection and safety, but not all routes of administration.

Fatigue does not increase limb asymmetry or induce proximal joint power shift during sprinting in habitual, multi-speed runners

This study examines how fatigue affects sprinting gait in runners, finding reduced inter-limb asymmetry and no shift in joint power from distal to proximal during fatigued sprinting.

The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition.

The paper identifies YTHDF2 as an m6A binding protein that promotes B cell to plasma cell transition in vitro and in chimeric mice.

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

This study identifies ZFP36 and ZFP36L1 as RNA binding proteins that regulate the timing and potency of CD8+ T cell differentiation and effector function during immune response.

Decadal changes in fire frequencies shift tree communities and functional traits

This study shows that long-term changes in fire frequency alter tree communities and functional traits across different ecosystems.

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality

This study identifies vimentin's role in driving pro-inflammatory responses in alveolar macrophages during influenza infection, linking it to lung injury and mortality.

Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen

This study recreates an antigen-driven germinal center in vitro using B and T cells, demonstrating the generation of high-affinity immunoglobulins through phagocytic antigen uptake.

Polypyrimidine Tract Binding Proteins are essential for B cell development

This study shows PTBP1 and PTBP2 regulate B cell development by controlling cell cycle progression through mRNA splicing and kinase activity.

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

This study shows that myeloid Trib1 promotes early atherosclerosis by enhancing foam cell formation through increased lipid uptake and OLR1 expression.